Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • HDAC
    (181)
  • Apoptosis
    (51)
  • Autophagy
    (20)
  • HIV Protease
    (7)
  • Mitophagy
    (4)
  • PI3K
    (4)
  • GABA Receptor
    (3)
  • Parasite
    (3)
  • Reactive Oxygen Species
    (3)
  • Others
    (112)
Filter
Search Result
Results for "

HDAC inhibitor

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    334
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    2
    TargetMol | Peptide_Products
  • Dye Reagents
    2
    TargetMol | Dye_Reagents
  • PROTAC Products
    7
    TargetMol | PROTAC
  • Natural Products
    17
    TargetMol | Natural_Products
  • Reagent Kits
    1
    TargetMol | Reagent_Kits
  • Recombinant Protein
    1
    TargetMol | Recombinant_Protein
  • Isotope Products
    3
    TargetMol | Isotope_Products
Vorinostat
suberoylanilide hydroxamic acid, SAHA, MK0683
T1583149647-78-9
Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1 2 3 6 7 11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and induces apoptosis.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
MPI_5a
T161291259296-46-2
MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM).
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Hot
ITSA-1
ITSA1
T3358200626-61-5
ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but shows no activity towards other HDAC inhibitors.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
Tucidinostat
HBI-8000, CS 055, Chidamide
T44811616493-44-7
Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1 2 3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 11 (IC50: 733 432 nM), and shows no effect on HDAC4 5 6 7 9.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
romidepsin
NSC 630176, FR 901228, FK 228, Depsipeptide
T6006128517-07-7
Romidepsin (FR 901228) is an HDAC inhibitor that inhibits HDAC1 2 4 6 (IC50=36 47 510 1400 nM). Romidepsin has antitumor activity and can be used for the treatment of peripheral T-cell lymphoma and cutaneous T-cell lymphoma.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
Trichostatin A
TSA
T627058880-19-6
Trichostatin A (TSA), a natural derivative of diene isohydroxamic acids, is a specific and reversible histone deacetylase inhibitor (IC50=1.8 nM) that induces hyperacetylation of core histones to regulate chromatin structure.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
Tasquinimod
ABR-215050
T6695254964-60-8
Tasquinimod (ABR-215050) is an oral antiangiogenic agent with potential antitumor activity. It is also an S100A9 inhibitor and binds to the HDAC4Zn2+ binding structural domain with Kd values between 10 and 30 nM.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
Valproic Acid
VPA, Sodium valproate, Depakine, 2-Propylvaleric Acid, 2-Propylpentanoic Acid
T706499-66-1
Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
ACY-957
HDAC Inhibitor C001
T102451609389-52-7In house
ACY-957 (HDAC Inhibitor C001) is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1 2 3) and shows no inhibition on HDAC4 5 6 7 8 9.
  • Inquiry Price
6-8 weeks
Size
QTY
CRA-026440 hydrochloride
CRA-026440 hydrochloride(847460-34-8 Free base)
T10883L847459-98-7In house
CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor. CRA-026440 hydrochloride exhibits Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM, respectively. CRA-026440 hydrochloride exhibits antitumor and antiangiogenic activities.
  • Inquiry Price
Size
QTY
SS-208
T169362245942-72-5In house
SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.
  • Inquiry Price
6-8 weeks
Size
QTY
R306465
JNJ 16241199, JNJ16241199, JNJ-16241199, R-306465, R 306465
T21324604769-01-9In house
R306465 (JNJ-16241199) is an orally active and selective class I histone deacetylase (HDAC 1) inhibitor with an IC50 of 3.3 nM. R306465 has a broad spectrum of antitumor activity, can induce histone 3 acetylation, and induce apoptosis, and can be used to study solid tumors and hematological malignancies.
  • Inquiry Price
6-8 weeks
Size
QTY
HDAC8-IN-20a
HDAC8IN20a, HDAC8 inhibitor-20a, HDAC8 inhibitor 20a, HDAC8 IN 20a
T241331884231-52-0In house
HDAC8-IN-20a (HDAC8 inhibitor-20a) is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM. HDAC8-IN-20a blocks activation of growth receptor survival signals.
  • Inquiry Price
6-8 weeks
Size
QTY
Crebinostat
T270831092061-61-4In house
Crebinostat is a potent histone deacetylase (HDAC) inhibitor, targeting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively. It increases the density of synapsin-1 punctae along dendrites in neurons in vitro, modulates chromatin-mediated neuroplasticity, and enhances memory in mice. Additionally, Crebinostat induces histone H3 and H4 acetylation and enhances the expression of Egr1, a cAMP-responsive element binding protein (CREB) target gene.
  • Inquiry Price
6-8weeks
Size
QTY
Patamostat mesylate
E-3123 mesylate, E3123 mesylate, E 3123 mesylate
T38521114568-32-0In house
Patamostat mesylate (E-3123) is a potent protease inhibitor with IC50 values of 39 nM for trypsin, 950 nM for plasmin, and 1.9 μM for thrombin. This compound demonstrates promising potential in suppressing the pathogenesis and development of acute pancreatitis.
  • Inquiry Price
Size
QTY
MPT0G211
T606162151853-97-1In house
MPT0G211 is a highly selective and orally active HDAC6 inhibitor (IC50=0.291 nM) that has neuroprotective effects and has shown anti-metastatic activity in human breast cancer cells. MPT0G211 has 1,000 times more affinity for HDAC6 than other HDAC subtypes. MPT0G211 can cross the blood-brain barrier and could be used to improve tau phosphorylation and cognitive deficits in Alzheimer's disease models.
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Sale
mtor/hdac-in-1
T633992815286-02-1In house
mTOR HDAC-IN-1 (Compound 50) is a dual inhibitor of mTOR and HDAC, with IC50 values of 0.49 nM and 0.91 nM, respectively, holding potential as an anti-cancer agent [1].
  • Inquiry Price
3-6 months
Size
QTY
mTOR/HDAC-IN-1 HCl
mTOR HDAC-IN-1 HCl(2815286-02-1 Free base)
T63399L In house
mTOR HDAC-IN-1 HCl is a potent dual inhibitor of mTOR and HDAC with potential anti-inflammatory, anti-proliferative, autophagy and apoptosis-inducing effects for cancer research.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
ST7612AA1
T706921428535-92-5In house
ST7612AA1 is a novel potent and oral HDCA inhibitor that acts as an HIV-1 latency reactivator. ST7612AA1 showed significant antitumor activity at low concentrations in vitro and in vivo. ST7612AA1 has potential anticancer activity and can be used to study malaria.
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Sale
MC2590
T735152284460-01-9In house
MC2590 is a potent and selective histone deacetylase (HDAC) inhibitor that inhibits HDAC1-3, -6, -8, and -10 activities, induces cell cycle arrest, and promotes apoptosis.
  • Inquiry Price
8-10 weeks
Size
QTY
Bufexamac
Bufexamic acid
T08672438-72-4
Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.
  • Inquiry Price
Size
QTY
Theophylline monohydrate
Quibron
T1083L5967-84-0
Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Physiologically, this agent relaxes the bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates the cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm.
  • Inquiry Price
Size
QTY
Sodium butanoate
Sodium Butyrate, Butanoic acid sodium salt
T1393156-54-7
Sodium butanoate (Sodium Butyrate) is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs).
  • Inquiry Price
Size
QTY
Sodium 4-phenylbutyrate
TriButyrate, Sodium Phenylbutyrate, Buphenyl
T15351716-12-7
Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.
  • Inquiry Price
Size
QTY